Glanzmann's disease; Thrombasthenia - Glanzmann
Glanzmann thrombasthenia is a rare disorder of blood platelets. Platelets are a part of the blood that aids in blood clotting.
Glanzmann thrombasthenia is caused by the lack of a protein that is normally on the surface of platelets. This substance is needed for platelets to clump together to form blood clots.
The condition is congenital, which means it is present from birth. There are several genetic abnormalities that can cause the condition.
Symptoms may include any of the following:
The following tests may be used to diagnose this condition:
Other tests may be needed. Family members may also need to be tested.
There is no specific treatment for this disorder. Platelet transfusions may be given to people who are having severe bleeding.
The following organizations are good resources for information on Glanzmann thrombasthenia:
Glanzmann thrombasthenia is a lifelong condition, and there is no cure. You should take special steps to try to avoid bleeding if you have this condition.
Anyone with a bleeding disorder should avoid taking aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen. These drugs can prolong bleeding times by preventing platelets from clumping.
Complications may include:
Call your health care provider if:
Glanzmann thrombasthenia is an inherited condition. There is no known prevention.
Bhatt MD, Ho K, Chan AKC. Disorders of coagulation in the neonate. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 150.
Nichols WL. Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 173.BACK TO TOP
Review Date: 1/29/2019
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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