Willis-Ekbom disease; Nocturnal myoclonus; RLS; Akathisia
Restless legs syndrome (RLS) is a nervous system problem that causes you to feel an unstoppable urge to get up and pace or walk. You feel uncomfortable unless you move your legs. Moving stops the unpleasant feeling for a short time.
This disorder is also known as restless legs syndrome/Willis-Ekbom disease (RLS/WED).
No one knows exactly what causes RLS. It may be due to a problem with the way brain cells use dopamine. Dopamine is a brain chemical that helps with muscle movement.
RLS may be linked to some other conditions. It may occur more often in people with:
RLS may also occur in people who:
RLS occurs most often in middle-aged and older adults. Women are more likely to have RLS than men.
RLS is commonly passed down in families. This may be a factor when symptoms start at a younger age.
RLS leads to unpleasant feelings in your lower legs. These feelings cause an unstoppable urge to move your legs. You may feel:
Symptoms can make it difficult to sit during air or car travel, or through classes or meetings.
Stress or emotional upset can make symptoms worse.
Most people with RLS have rhythmic leg movements when they sleep. This condition is called periodic limb movement disorder.
All of these symptoms make it hard to sleep. Lack of sleep can lead to:
There is no specific test for RLS. Your health care provider will take your medical history and do a physical exam. You may have blood tests and other exams to rule out conditions that can cause similar symptoms.
Usually, your provider will determine whether you have RLS based on your symptoms.
RLS can't be cured. However, treatment can help relieve symptoms.
Certain lifestyle changes may help you cope with the condition and ease symptoms.
Your provider may prescribe medicines to treat RLS.
Some medicines help control symptoms:
Other medicines can help you sleep:
Medicines to help you sleep may cause daytime sleepiness.
Treating conditions with similar symptoms such as peripheral neuropathy or iron deficiency can also help relieve symptoms.
RLS is not dangerous. However, it can be uncomfortable, making it hard to sleep and affecting your quality of life.
You may not be able to sleep well (insomnia).
Call for an appointment with your provider if:
There is no way to prevent RLS.
Allen RP, Montplaisir J, Walters AS, Ferini-Strambi L, Hogl B. Restless legs syndrome and periodic limb movements during sleep. In: Kryger M, Roth T, Dement WC, eds. Principles and Practice of Sleep Medicine. 6th ed. Philadelphia, PA: Elsevier; 2017:chap 95.
Avidan AY. Sleep and its disorders. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 101.
National Institute of Neurological Disorders and Stroke website. Restless legs syndrome fact sheet. www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Restless-Legs-Syndrome-Fact-Sheet. Updated November 15, 2021. Accessed November 18, 2021.
Winkelman JW, Armstrong MJ, Allen RP, et al. Practice guideline summary: treatment of restless legs syndrome in adults: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology. 2016;87(24):2585-2593. PMID: 27856776 pubmed.ncbi.nlm.nih.gov/27856776/.BACK TO TOP
Review Date: 7/26/2021
Reviewed By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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