Site Map

Prothrombin deficiency

Hypoprothrombinemia; Factor II deficiency; Dysprothrombinemia

Prothrombin deficiency is a disorder caused by a lack of a protein in the blood called prothrombin. It leads to problems with blood clotting (coagulation). Prothrombin is also known as factor II (factor two).

Images

I Would Like to Learn About:

Causes

When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should.

Prothrombin, or factor II, is one such coagulation factor. Prothrombin deficiency runs in families (inherited) and is very rare. Both parents must have the gene to pass the disorder on to their children. A family history of a bleeding disorder can be a risk factor.

Prothrombin deficiency can also be due to another condition or use of certain medicines. This is called acquired prothrombin deficiency. It can be caused by:

• Lack of vitamin K (some babies are born with vitamin K deficiency)
• Severe liver disease
• Use of medicines that prevent clotting (anticoagulants such as warfarin)

Symptoms

Symptoms may include any of the following:

• Abnormal bleeding after childbirth
• Heavy menstrual bleeding
• Bleeding after surgery
• Bleeding after trauma
• Bruising easily
• Nosebleeds that do not stop easily
• Umbilical cord bleeding after birth

Exams and Tests

Tests that may be done include:

• Factor II assay
• Partial thromboplastin time
• Prothrombin time (PT)
• Mixing study (a special PTT test to confirm prothrombin deficiency)

Treatment

Bleeding can be controlled by getting intravenous (IV) infusions of plasma or concentrates of clotting factors. If you lack vitamin K, you can take this vitamin by mouth, through injections under the skin, or through a vein (intravenously).

If you have this bleeding disorder, be sure to:

• Tell your health care providers before you have any kind of procedure, including surgery and dental work.
• Tell your family members because they may have the same disorder but do not know it yet.

Support Groups

These resources can provide more information on Factor VII deficiency:

• National Hemophilia Foundation: Other Factor Deficiencies -- www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies
• NIH Genetic and Rare Diseases Information Center -- rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency

Outlook (Prognosis)

The outcome is good with proper treatment.

Inherited prothrombin deficiency is a lifelong condition.

The outlook for acquired prothrombin deficiency depends on the cause. If it is caused by liver disease, the outcome depends on how well your liver disease can be treated. Taking vitamin K supplements will treat vitamin K deficiency.

Possible Complications

Severe bleeding in the organs can occur.

When to Contact a Medical Professional

Get emergency treatment right away if you have unexplained or long-term blood loss, or if you cannot control the bleeding.

Prevention

There is no known prevention for inherited prothrombin deficiency. When a lack of vitamin K is the cause, using vitamin K can help.

Related Information

Bleeding disorders
Vitamin K
Liver disease
Bile duct obstruction
Malabsorption

References

Gailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.

Hall JE. Hemostasis and blood coagulation. In: Hall JE, ed. Guyton and Hall Textbook of Medical Physiology. 13th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 37.

Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 174.

BACK TO TOP

Review Date: 1/29/2019  

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

A.D.A.M., Inc. is accredited by URAC, for Health Content Provider (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics. This site complies with the HONcode standard for trustworthy health information: verify here.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2021 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.