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Acquired platelet function defect

Acquired qualitative platelet disorders; Acquired disorders of platelet function

Acquired platelet function defects are conditions that prevent clotting elements in the blood called platelets from working as they should. The term acquired means these conditions are not present at birth.

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Blood clot formation
Blood clots

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Causes

Platelet disorders can affect the number of platelets, how well they function, or both. A platelet disorder affects normal blood clotting.

Disorders that can cause problems in platelet function include:

Other causes include:

Symptoms

Symptoms may include any of the following:

Exams and Tests

Tests that may done include:

Treatment

Treatment is aimed at fixing the cause of the problem:

Outlook (Prognosis)

Most of the time, treating the cause of the problem corrects the defect.

Possible Complications

Complications may include:

When to Contact a Medical Professional

Call your health care provider if:

Prevention

Using medicines as directed can reduce the risk of drug-related acquired platelet function defects. Treating other disorders may also reduce the risk. Some cases cannot be prevented.

Related Information

Platelet count
Polycythemia vera
Thrombocytopenia
Chronic myelogenous leukemia (CML)
Myelofibrosis
Acute kidney failure
Multiple myeloma
Anemia

References

Diz-Kucukkaya R, Lopez JA. Acquired disorders of platelet function. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 130.

Hall JE. Hemostasis and blood coagulation. In: Hall JE, ed. Guyton and Hall Textbook of Medical Physiology. 13th ed. Philadelphia, PA: Elsevier; 2016:chap 37.

Jobe SM, Di Paola J. Congenital and acquired disorders of platelet function and number. In: Kitchens CS, Kessler CM, Konkle BA, Streiff MB, Garcia DA, eds. Consultative Hemostasis and Thrombosis. 4th ed. Philadelphia, PA: Elsevier; 2019:chap 9.

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Review Date: 1/29/2019  

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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