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Interstitial nephritis

Tubulointerstitial nephritis; Nephritis - interstitial; Acute interstitial (allergic) nephritis

Interstitial nephritis is a kidney disorder in which the spaces between the kidney tubules become swollen (inflamed). This can cause problems with the way your kidneys work.

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Causes

Interstitial nephritis may be temporary (acute), or it may be long-lasting (chronic) and get worse over time.

The acute form of interstitial nephritis is most often caused by side effects of certain drugs.

The following can cause interstitial nephritis:

Symptoms

Interstitial nephritis can cause mild to severe kidney problems, including acute kidney failure. In about half of cases, people will have decreased urine output and other signs of acute kidney failure.

Symptoms of this condition may include:

Exams and Tests

The health care provider will perform a physical exam. This may reveal:

Common tests include:

Treatment

Treatment depends on the cause of the problem. Avoiding medicines that lead to this condition may quickly relieve symptoms.

Limiting salt and fluid in the diet can improve swelling and high blood pressure. Limiting protein in the diet can help control the buildup of waste products in the blood (azotemia), which can lead to symptoms of acute kidney failure.

If dialysis is necessary, it usually is required for only a short time.

Corticosteroids or stronger anti-inflammatory medicines such as cyclophosphamide can sometimes be helpful.

Outlook (Prognosis)

Most often, interstitial nephritis is a short-term disorder. In rare cases, it can cause permanent damage, including long-term (chronic) kidney failure.

Acute interstitial nephritis may be more severe and more likely to lead to long-term or permanent kidney damage in older people.

Possible Complications

Metabolic acidosis can occur because the kidneys aren't able to remove enough acid. The disorder can lead to acute or chronic kidney failure or end-stage kidney disease.

When to Contact a Medical Professional

Call your provider if you have symptoms of interstitial nephritis.

If you have interstitial nephritis, call your provider if you get new symptoms, especially if you are less alert or have a decrease in urine output.

Prevention

Often, the disorder can't be prevented. Avoiding or reducing your use of medicines that can cause this condition can help reduce your risk. If needed, your provider will tell you which medicines to stop or reduce.

Related Information

Renal
Chronic
Analgesic nephropathy
Allergic reactions
Acute
Acute kidney failure
Urine output - decreased
Metabolic acidosis
Chronic kidney disease
End-stage kidney disease
Injury - kidney and ureter

References

Kelly CJ, Neilson EJ. Tubulointerstitial diseases. In: Skorecki K, Chertow GM, Taal MW, Yu ASL, eds. Brenner and Rector's The Kidney. 10th ed. Philadelphia, PA: Elsevier; 2016:chap 36.

Nangaku M. Chronic interstitial nephritis. In: Johnson RJ, Feehally J, Floege J, eds. Comprehensive Clinical Nephrology. 5th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 64.

Neilson EG. Tubulointerstitial nephritis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 122.

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Review Date: 8/1/2017  

Reviewed By: Walead Latif, MD, nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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