Bleeding disorders are a group of conditions in which there is a problem with the body's blood clotting process. These disorders can lead to heavy and prolonged bleeding after an injury. Bleeding can also begin on its own.
Specific bleeding disorders include:
Normal blood clotting involves blood components, called platelets, and as many as 20 different plasma proteins. These are known as blood clotting or coagulation factors. These factors interact with other chemicals to form a substance that stops bleeding called fibrin.
Problems can occur when certain factors are low or missing. Bleeding problems can range from mild to severe.
Some bleeding disorders are present at birth and are passed down through families (inherited). Others develop from:
Bleeding disorders can also result from a problem with the number or function of the blood cells that promote blood clotting (platelets). These disorders can also be either inherited or develop later (acquired). The side effects of certain drugs often lead to the acquired forms.
Symptoms may include any of the following:
The problems that occur depend on the specific bleeding disorder, and how severe it is.
Tests that may be done include:
Treatment depends on the type of disorder. It may include:
More information and support for people with bleeding disorders and their families can be found at:
Outcome also depends on the disorder. Most primary bleeding disorders can be managed. When the disorder is due to diseases, such as DIC, the outcome will depend on how well the underlying disease can be treated.
Complications may include:
Other complications can occur, depending on the disorder.
Call your health care provider if you notice any unusual or severe bleeding.
Prevention depends on the specific disorder.
Gailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.
Hall JE, Hall ME. Hemostasis and blood coagulation. In: Hall JE, Hall ME, eds. Guyton and Hall Textbook of Medical Physiology. 14th ed. Philadelphia, PA: Elsevier; 2021:chap 37.
Neff AT. Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 164.BACK TO TOP
Review Date: 1/19/2021
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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