Chlorpheniramine/ibuprofen/phenylephrine (By mouth)
Chlorpheniramine Maleate (klor-fen-IR-a-meen MAL-ee-ate), Ibuprofen (eye-bue-PROE-fen), Phenylephrine Hydrochloride (fen-il-EF-rin hye-droe-KLOR-ide)
Relieves symptoms of allergies and cold, including runny or stuffy nose. This medicine contains an NSAID.
Advil Allergy & Congestion ReliefThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to chlorpheniramine, ibuprofen, phenylephrine, or similar medicines, or right before or after a heart surgery.
How to Use This Medicine:
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- It is best to take this medicine with food or milk.
- Follow the instructions on the medicine label if you are using this medicine without a prescription.
- Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Do not use this medicine if you are using or have used an MAO inhibitor (MAOI) within the past 2 weeks.
- Some medicines can affect how chlorpheniramine/ibuprofen/phenylephrine works. Tell your doctor if you are using any of the following:
- Blood thinner
- Diuretic (water pill)
- Other cold medicine
- Other NSAIDs (including aspirin, naproxen)
- Steroid medicine
- Do not drink 3 or more alcoholic drinks while you are using this medicine.
- Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant. Do not use this medicine during the later part of your pregnancy, unless your doctor tells you to.
- Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, high blood pressure, asthma, diabetes, glaucoma, thyroid problems, trouble urinating, lung or breathing problems (including bronchitis, emphysema), or a history of stomach problems (including heartburn) or stroke.
- This medicine may cause the following problems:
- Increased risk of heart attack, heart failure, or stroke
- Stomach bleeding
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
- Call your doctor if your symptoms do not improve or if they get worse.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain that may spread, coughing up blood, nausea, unusual sweating, fainting
- Numbness or weakness on one side of your body, pain in your lower leg
- Severe constipation, stomach pain, vomiting of blood, bloody or black, tarry stools
- Sudden or severe headache, problems with vision, speech, or walking
- Swelling in your hands, ankles, or feet
- Trouble breathing, cold sweat, bluish-colored skin
If you notice these less serious side effects, talk with your doctor:
- Dizziness, nervousness, trouble sleeping
- Unusual excitement, especially in children
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 6/2/2022