Posaconazole (By injection)
Treats or prevents fungus infections.
NoxafilThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to posaconazole or similar medicines.
How to Use This Medicine:
- Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
- A nurse or other health provider will give you this medicine.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Do not use this medicine together with atorvastatin, lovastatin, pimozide, quinidine, simvastatin, sirolimus, venetoclax, or an ergot medicine (including ergotamine, dihydroergotamine).
- Some medicines can affect how posaconazole works. Tell your doctor if you are using any of the following:
- Cyclosporine, digoxin, efavirenz, glipizide, phenytoin, rifabutin, tacrolimus
- Benzodiazepine medicine (including alprazolam, triazolam)
- Blood pressure medicine (including verapamil, diltiazem, felodipine, nifedipine, nicardipine)
- Medicine to treat HIV/AIDS (including atazanavir, efavirenz, fosamprenavir, ritonavir)
- Vinca alkaloids (including vinblastine, vincristine)
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or heart rhythm problems (including QT prolongation).
- This medicine may cause the following problems:
- Heart rhythm problems, including QT prolongation, torsades de pointes
- Liver problems
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
- Dry mouth, increased thirst, muscle cramps
- Fast, slow, pounding, or uneven heartbeat
- Fever, chills, cough, sore throat, body aches
- Rapid weight gain, swelling in your hands, ankles, or feet
- Severe diarrhea
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Mild diarrhea, constipation
- Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
- Sores or white patches on your lips, mouth, or throat
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 6/2/2022