Dornase alfa (By breathing)
Dornase Alfa (DOR-nase AL-fa)
Treats cystic fibrosis.
PulmozymeThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:This medicine is not right for everyone. Do not use it if you had an allergic reaction to dornase alfa or Chinese hamster ovary cell products.
How to Use This Medicine:
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- This medicine should be used with the eRapid nebulizer system or jet nebulizer connected to an air compressor. The nebulizer turns the medicine into a fine mist that you breathe in through your mouth. Do not mix any other medicines with the solution. To use:
- This medicine comes in small plastic containers called ampules. Each ampule contains one full dose of dornase alfa. Do not use an ampule that has already been opened. Do not use a cloudy or discolored inhalation solution.
- Remove the ampule from the pouch. Place the inhalation solution in the medicine reservoir or nebulizer cup on the machine.
- Connect the nebulizer to the face mask or mouthpiece, then connect the nebulizer to the compressor.
- Use the mouthpiece of the nebulizer to breathe in Pulmozyme®. Do not use a face mask with the nebulizer because less medicine will get into your lungs.
- Patients who are unable to breathe in or breathe out by mouth may use the PARI BABY nebulizer with the supplied face mask. Make sure you understand exactly how to use this medicine in the nebulizer.
- Use the nebulizer for about 10 to 15 minutes, or until the medicine in the nebulizer cup is gone.
- Follow the manufacturer's directions for care and cleaning of the nebulizer and compressor.
- Do not mix any other medicine in the nebulizer with dornase alfa.
- Missed dose: Use your medicine as soon as you remember. If it is almost time for your next dose, wait until then and use a regular dose. Do not use extra medicine to make up for a missed dose.
- Store the medicine in the refrigerator in its foil pouch and protect it from direct light. Do not freeze. Do not leave the medicine at room temperature for more than 24 hours.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain, trouble breathing
- Fever, cough, runny nose, sore throat, voice changes
If you notice these less serious side effects, talk with your doctor:
- Redness, pain, swelling, or itching of eyes
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 6/2/2022