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Barrett esophagus

Barrett's esophagus; GERD - Barrett; Reflux - Barrett

Barrett esophagus (BE) is a disorder in which the lining of the esophagus is damaged by stomach acid. The esophagus is also called the food pipe, and it connects your throat to your stomach.

People with BE have an increased risk for cancer in the area involved. However, cancer is not common.

Causes

When you eat, food passes from your throat to your stomach through the esophagus. A ring of muscle fibers in the lower esophagus keeps stomach contents from moving backward.

If these muscles do not close tightly, harsh stomach acid can leak into the esophagus. This is called reflux or gastroesophageal reflux (GERD). It may cause tissue damage over time. The lining becomes similar to that of the stomach.

BE occurs more often in men than women. People who have had GERD for a long time are more likely to have this condition.

Symptoms

BE itself does not cause symptoms. The acid reflux that causes BE often leads to symptoms of heartburn. Many people with this condition do not have any symptoms.

Exams and Tests

You may need an endoscopy if GERD symptoms are severe or come back after treatment.

During the endoscopy, your endoscopist may take tissue samples (biopsies) from different parts of the esophagus. These samples help detect the condition. They also help look for changes that could lead to cancer.

Your provider may recommend a follow-up endoscopy to look for cell changes that indicate cancer at regular intervals.

Treatment

TREATMENT OF GERD

Treatment should improve acid reflux symptoms, and may keep BE from getting worse. Treatment may involve lifestyle changes and medicines such as:

  • Antacids after meals and at bedtime
  • Histamine H2 receptor blockers
  • Proton pump inhibitors
  • Avoiding use of tobacco, chocolate, and caffeine

Lifestyle changes, medicines, and anti-reflux surgery may help with symptoms of GERD. However, these steps will not make BE go away.

TREATMENT OF BARRETT ESOPHAGUS

Endoscopic biopsy can show changes in the cell that may be cancer. You provider may advise surgery or other procedures to treat it.

Some of the following procedures remove the harmful tissue in your esophagus:

  • Photodynamic therapy (PDT) uses a special laser device, called an esophageal balloon, along with a medicine called Photofrin.
  • Other procedures use different types of high energy to destroy the precancerous tissue.
  • Surgery to remove the abnormal lining.

Outlook (Prognosis)

Treatment should improve acid reflux symptoms and may keep BE from getting worse. None of these treatments will reverse the changes that may lead to cancer.

People with chronic GERD or Barrett esophagitis generally need to be monitored for cancer of the esophagus.

When to Contact a Medical Professional

Call your provider if:

  • Heartburn lasts for longer than a few days, or you have pain or problems swallowing.
  • You have been diagnosed with BE and your symptoms get worse.
  • You develop new symptoms (such as weight loss, problems swallowing).

Prevention

Early detection and treatment of GERD may prevent BE.

References

Falk GW, Katzka DA. Diseases of the esophagus. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 129.

Jackson AS, Louie BE. Management of Barrett's esophagus. In: Cameron AM, Cameron JL, eds. Current Surgical Therapy. 13th ed. Philadelphia, PA: Elsevier; 2020:19-25.

Ku GY, Ilson DH. Cancer of the esophagus. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 71.

Shaheen NJ, Falk GW, Iyer PG, Gerson LB; American College of Gastroenterology. ACG clinical guideline: diagnosis and management of Barrett's esophagus. Am J Gastroenterol. 2016;111(1):30-50. PMID: 26526079 pubmed.ncbi.nlm.nih.gov/26526079/.

Text only

  • Digestive system

    Digestive system - illustration

    The esophagus, stomach, large and small intestine, aided by the liver, gallbladder and pancreas convert the nutritive components of food into energy and break down the non-nutritive components into waste to be excreted.

    Digestive system

    illustration

  • Esophagus and stomach anatomy

    Esophagus and stomach anatomy - illustration

    Food is swallowed and passes through the esophagus to the stomach, where the majority of digestion takes place.

    Esophagus and stomach anatomy

    illustration

    • Digestive system

      Digestive system - illustration

      The esophagus, stomach, large and small intestine, aided by the liver, gallbladder and pancreas convert the nutritive components of food into energy and break down the non-nutritive components into waste to be excreted.

      Digestive system

      illustration

    • Esophagus and stomach anatomy

      Esophagus and stomach anatomy - illustration

      Food is swallowed and passes through the esophagus to the stomach, where the majority of digestion takes place.

      Esophagus and stomach anatomy

      illustration

     

    Review Date: 1/13/2020

    Reviewed By: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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