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Thyroid peroxidase antibody

Thyroid antimicrosomal antibody; Antimicrosomal antibody; Microsomal antibody; Antithyroid microsomal antibody; TPOAb; Anti-TPO antibody

Microsomes are found inside thyroid cells. The body produces antibodies to microsomes when there has been damage to thyroid cells. The antithyroid microsomal antibody test measures these antibodies in the blood.

How the Test is Performed

A blood sample is needed.

How the Test will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

Why the Test is Performed

This test is done to confirm the cause of thyroid problems, including Hashimoto thyroiditis.

The test is also used to find out if an immune or autoimmune disorder is damaging the thyroid.

Normal Results

A negative test means the result is normal.

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or may test different specimens. Talk to your health care provider about the meaning of your specific test results.

What Abnormal Results Mean

A positive test may be due to:

  • Granulomatous thyroiditis (an immune reaction of the thyroid gland that often follows an upper respiratory infection)
  • Hashimoto thyroiditis (a reaction of the immune system against the thyroid gland)

High levels of these antibodies have also been linked with an increased risk of:

  • Miscarriage
  • Preeclampsia (high blood pressure and protein in the urine after the 20th week of pregnancy)
  • Premature birth
  • In vitro fertilization failure

Important: A positive result does not always mean that you have a thyroid condition or that you need treatment for your thyroid. A positive result may mean that you have a higher chance of developing thyroid disease in the future. This is often associated with a family history of thyroid disease.

Antithyroid microsomal antibodies may be seen in your blood if you have other autoimmune conditions, including:

Risks

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Multiple punctures to locate veins
  • Hematoma (blood buildup under the skin)
  • Infection (a slight risk any time the skin is broken)

References

Chang AY, Auchus RJ. Endocrine disturbances affecting reproduction. In: Strauss JF, Barbieri RL, eds. Yen & Jaffe's Reproductive Endocrinology. 8th ed. Philadelphia, PA: Elsevier; 2019:chap 24.

Chernecky CC, Berger BJ. Thyroid peroxidase (TPO, antimicrosomal antibody, antithyroid microsomal antibody) antibody - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:1080-1081.

Guber HA, Farag AF. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 24.

Salvatore D, Cohen R, Kopp PA, Larsen PR. Thyroid pathophysiology and diagnostic evaluation. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 11.

Weiss RE, Refetoff S. Thyroid function testing. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 78.

Text only

  • Blood test

    Blood test - illustration

    Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.

    Blood test

    illustration

    • Blood test

      Blood test - illustration

      Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.

      Blood test

      illustration

    A Closer Look

     

    Tests for Thyroid peroxidase antibody

     
     

    Review Date: 1/26/2020

    Reviewed By: Brent Wisse, MD, board certified in Metabolism/Endocrinology, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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